The first blast rocked Tripoli at 10:45 am (0845 GMT) and was followed by three others.
The explosions were strongly felt in a hotel housing foreign correspondents in Tripoli.
The complex that includes Khadafi’s residence has been consistently targeted by a NATO air campaign in Libya.
On Monday, NATO air raids on Tripoli targeted the communications of the battered regime, hitting offices of the state broadcaster and his military intelligence headquarters, officials said.
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